Application of cabozantinib

The invention discloses a new application of a small molecule tyrosine kinase inhibitor cabozantinib, and relates to the technical field of medicines. The specific new application of the small molecular tyrosine kinase inhibitor cabozantinib is as follows: the cabozantinib or pharmaceutically, healthcare or food acceptable salt or ester or derivative thereof, or a mixture thereof can degrade and mutate p53Y220C protein through a ubiquitin proteasome way; compared with tumor cells expressing other mutant p53 or wild-type tumor cells, the ovarian cancer cells carrying the expression mutant p53Y220C are more sensitive to treatment of cabozantinib and can be used for preparing substances for treating ovarian cancer, inhibiting growth of the ovarian cancer cells and/or inducing apoptosis of the ovarian cancer cells. According to the discovery, the application of the cabozantinib in treatment is expanded, and a novel treatment strategy is provided for ovarian cancer patients carrying the mutant p53Y220C. 本发明公开了小分子酪