Enhancing immune response by targeting antigen expression

The present disclosure includes an immunogenic composition comprising an effective amount of a therapeutically engineered bacteriophage and a pharmaceutically acceptable carrier. In certain aspects, the disclosure includes methods of stimulating an immune response in a subject, comprising administering to the subject a composition comprising an effective amount of a therapeutically engineered bacteriophage. In certain aspects, the disclosure includes methods for treating, ameliorating and/or preventing coronavirus infection in a subject, comprising administering a composition comprising an effective amount of a therapeutically engineered bacteriophage. 本公开包括免疫原性组合物，其包含有效量的治疗性改造噬菌体和药学上可接受的载剂。在某些方面中，本公开包括在对象中刺激免疫应答的方法，包括向所述对象施用包含有效量的治疗性改造噬菌体的组合物。在某些方面中，本公开包括用于治疗、改善和/或预防对象中的冠状病毒感染的方法，包括施用包含有效量的治疗性改造噬菌体的组合物。