Fluvoxamine maleate tablet and preparation method thereof

The invention provides a fluvoxamine maleate tablet and a preparation method thereof, and belongs to the technical field of medicines.The preparation method comprises the steps that mesoporous hollow titanium dioxide nanospheres are prepared through a sol-gel method and then added into magnesium alu...

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Bibliographische Detailangaben
Hauptverfasser: LIU LIEQIANG, JI YU, ZHANG XINGWEI, XIA NENGBIN, LI YADONG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention provides a fluvoxamine maleate tablet and a preparation method thereof, and belongs to the technical field of medicines.The preparation method comprises the steps that mesoporous hollow titanium dioxide nanospheres are prepared through a sol-gel method and then added into magnesium aluminum silicate sol, coated nanospheres are prepared, then fluvoxamine maleate is prepared into a self-emulsifying drug delivery system, and the fluvoxamine maleate tablet is prepared. And dropwise adding the mixture into the coated nanospheres, drying and sieving to prepare a cured self-microemulsion system, uniformly mixing the cured self-microemulsion system with auxiliary materials, and directly tabletting to prepare the fluvoxamine maleate tablet. The fluvoxamine maleate tablet prepared by the invention is prepared by adopting a direct tabletting method, the generation of impurities such as isomers and adducts in the fluvoxamine maleate in a humid or high-temperature environment is avoided, and meanwhile, a sus