Method for producing antibody-drug conjugate
A method for producing an antibody-drug conjugate composition, which comprises: (i) a step of reacting an antibody with a reducing agent to obtain an antibody having a thiol group; and (ii) a step of reacting the drug linker intermediate with the antibody having the thiol group obtained in step (i),...
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| creator | SASO RIKA FUKATSU DAISUKE SATO HITOSHI |
| description | A method for producing an antibody-drug conjugate composition, which comprises: (i) a step of reacting an antibody with a reducing agent to obtain an antibody having a thiol group; and (ii) a step of reacting the drug linker intermediate with the antibody having the thiol group obtained in step (i), wherein step (i) is performed until the composition ratio of the antibody having four heavy-light inter-chain thiol and the composition ratio of the antibody having four heavy-heavy inter-chain thiol reach stable values.
抗体-药物缀合物组合物的制造方法，其包括：(i)使抗体与还原剂反应以获得具有硫醇基的抗体的步骤；然后(ii)使药物接头中间体与步骤(i)中获得的具有硫醇基的抗体反应的步骤，其中进行步骤(i)直至具有四个重-轻链间硫醇的抗体的组成比和具有四个重-重链间硫醇的抗体的组成比达到稳定值。 |
| format | Patent |
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抗体-药物缀合物组合物的制造方法，其包括：(i)使抗体与还原剂反应以获得具有硫醇基的抗体的步骤；然后(ii)使药物接头中间体与步骤(i)中获得的具有硫醇基的抗体反应的步骤，其中进行步骤(i)直至具有四个重-轻链间硫醇的抗体的组成比和具有四个重-重链间硫醇的抗体的组成比达到稳定值。</description><language>chi ; eng</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230523&DB=EPODOC&CC=CN&NR=116157417A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230523&DB=EPODOC&CC=CN&NR=116157417A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SASO RIKA</creatorcontrib><creatorcontrib>FUKATSU DAISUKE</creatorcontrib><creatorcontrib>SATO HITOSHI</creatorcontrib><title>Method for producing antibody-drug conjugate</title><description>A method for producing an antibody-drug conjugate composition, which comprises: (i) a step of reacting an antibody with a reducing agent to obtain an antibody having a thiol group; and (ii) a step of reacting the drug linker intermediate with the antibody having the thiol group obtained in step (i), wherein step (i) is performed until the composition ratio of the antibody having four heavy-light inter-chain thiol and the composition ratio of the antibody having four heavy-heavy inter-chain thiol reach stable values.
抗体-药物缀合物组合物的制造方法，其包括：(i)使抗体与还原剂反应以获得具有硫醇基的抗体的步骤；然后(ii)使药物接头中间体与步骤(i)中获得的具有硫醇基的抗体反应的步骤，其中进行步骤(i)直至具有四个重-轻链间硫醇的抗体的组成比和具有四个重-重链间硫醇的抗体的组成比达到稳定值。</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDxTS3JyE9RSMsvUigoyk8pTc7MS1dIzCvJTMpPqdRNKSpNV0jOz8sqTU8sSeVhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaGZoam5iaG5o7GxKgBAKh9KgE</recordid><startdate>20230523</startdate><enddate>20230523</enddate><creator>SASO RIKA</creator><creator>FUKATSU DAISUKE</creator><creator>SATO HITOSHI</creator><scope>EVB</scope></search><sort><creationdate>20230523</creationdate><title>Method for producing antibody-drug conjugate</title><author>SASO RIKA ; FUKATSU DAISUKE ; SATO HITOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116157417A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>SASO RIKA</creatorcontrib><creatorcontrib>FUKATSU DAISUKE</creatorcontrib><creatorcontrib>SATO HITOSHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SASO RIKA</au><au>FUKATSU DAISUKE</au><au>SATO HITOSHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for producing antibody-drug conjugate</title><date>2023-05-23</date><risdate>2023</risdate><abstract>A method for producing an antibody-drug conjugate composition, which comprises: (i) a step of reacting an antibody with a reducing agent to obtain an antibody having a thiol group; and (ii) a step of reacting the drug linker intermediate with the antibody having the thiol group obtained in step (i), wherein step (i) is performed until the composition ratio of the antibody having four heavy-light inter-chain thiol and the composition ratio of the antibody having four heavy-heavy inter-chain thiol reach stable values.
抗体-药物缀合物组合物的制造方法，其包括：(i)使抗体与还原剂反应以获得具有硫醇基的抗体的步骤；然后(ii)使药物接头中间体与步骤(i)中获得的具有硫醇基的抗体反应的步骤，其中进行步骤(i)直至具有四个重-轻链间硫醇的抗体的组成比和具有四个重-重链间硫醇的抗体的组成比达到稳定值。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | Method for producing antibody-drug conjugate |
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