Application of LncRNA as radon exposure early damage diagnosis molecular marker and screening method

The invention relates to application of LncRNA (long non-coding ribonucleic acid) serving as a radon exposure early injury diagnosis molecular marker and a screening method of the LncRNA serving as the radon exposure early injury diagnosis molecular marker. One or more of differential genes Lnc-LGSN...

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Hauptverfasser: DANG XUHONG, ZHANG XIAOQUAN, YANG BIAO, LIU XIAOMING, CHAI DONGLIANG, REN YUE, DONG JUANCONG, ZHANG RUIFENG, CHENG JIAO, ZHANG ZHONGXIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to application of LncRNA (long non-coding ribonucleic acid) serving as a radon exposure early injury diagnosis molecular marker and a screening method of the LncRNA serving as the radon exposure early injury diagnosis molecular marker. One or more of differential genes Lnc-LGSN-3: 1, NONHSAT164422 and NONHSAT15348, of which the gene expression up-regulation/down-regulation has a response relationship with the irradiation dose, are used as radon exposure damage diagnosis molecular markers, and radiation exposure diagnosis can be conveniently, accurately and quantitatively carried out. According to the method, the human bronchial epithelial cells BEAS-2B are subjected to fractional accumulative irradiation through the alpha particle irradiation device, and the model of early injury of the human bronchial epithelial cells caused by alpha particle irradiation is successfully constructed; then, screening differentially expressed LncRNA molecules in the model cells at the early injury stage of