Saccharomyces cerevisiae strain for producing retinol and application thereof

The invention discloses a saccharomyces cerevisiae strain for producing retinol and application thereof.The construction method comprises the steps that saccharomyces cerevisiae serves as an original strain, exogenous genes crtE, crtB, crtI, crtYB and blh are introduced, a retinol synthesis route is constructed in yeast cells, a metabolic network of retinol is optimized through multi-element modular engineering, the retinol synthesis route is divided into five modules for metabolism regulation, and the retinol is obtained. The method comprises the following steps: mutating a dehydrogenase gene ENV9, knocking out a transporter Pdr5p through transporter engineering, finally improving the catalytic efficiency of a key enzyme by utilizing semi-rational transformation of the enzyme, and combining and integrating the mutated dehydrogenase gene ENV9 and a dehydrogenase gene ybbo from escherichia coli into a saccharomyces cerevisiae genome, so that the yield of retinol reaches 387.4 mg/L. Finally, the fermentation co