Preparation and application of < 131 > I loaded nano preparation

The invention discloses preparation and application of a < 131 > I loaded nano preparation. The preparation method comprises the following steps: firstly, preparing a 2-HP-beta-CD-NaI3 inclusion compound, and then, combining the inclusion compound with albumin to prepare an HSA-2-HP-beta-CD-NaI3 nano preparation. The iodine-containing nano preparation is prepared by loading radioactive iodine nuclides on the cyclodextrin carrier and wrapping the carrier with albumin, the biocompatibility is high, immunoreaction is not generated, meanwhile, by changing the adsorption quantity of < 131 > I nuclides on the carrier, the radiation dose can be controlled, the method becomes a novel method for treating thyroid cancer, the steps are simple, and the cost is low. The product quality is stable and the application prospect is good. 本发明公开了载131I纳米制剂的制备和应用，先进行2-HP-β-CD-NaI3包合物的制备，然后包合物与白蛋白结合进行HSA-2-HP-β-CD-NaI3纳米制剂的制备。本发明通过将放射性碘核素负载在环糊精载体上，利用白蛋白包裹，制备成含碘纳米制剂，高生物相容性，不产生免疫反应，同时通过改变载体上131I核素的吸附量，可实现放射剂量的控制，使其成为甲状腺癌治疗的新型方法，步骤简单，