Application of TIM-3 palmitoylation modified and targeted polypeptide in tumor immunotherapy

The invention relates to application of a TIM-3 palmitoylation modified and targeted polypeptide in tumor immunotherapy. According to the technical scheme provided by the invention, the influence of TIM-3 palmitoylation on cell membrane expression and protein stability is clarified, the action mecha...

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Hauptverfasser:	LIANG XIAOHONG, YUE XUETIAN, LI MENGZHEN, LI CHUNYANG, MA SHUAIYA, WU ZHUANCHANG, XIAO RONG, REN CAIYUE, GAO LIFEN, SUN YANG, MA CHUNHONG, ZHANG ZHAOYING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to application of a TIM-3 palmitoylation modified and targeted polypeptide in tumor immunotherapy. According to the technical scheme provided by the invention, the influence of TIM-3 palmitoylation on cell membrane expression and protein stability is clarified, the action mechanism of TIM-3 palmitoylation mediated CTL/NK cell depletion is researched, and the significance of TIM-3 palmitoylation on stable expression of TIM-3 is improved. A blocking polypeptide targeting a TIM-3 palmitoylation site is designed, a targeting intervention strategy is provided for inhibiting TIM-3 expression, and a new direction is provided for anti-tumor immunotherapy of targeting intervention TIM-3 palmitoylation. 本发明涉及一种TIM-3棕榈酰化修饰及靶向多肽在肿瘤免疫治疗中的应用。本发明提供的技术方案明确了TIM-3棕榈酰化对其细胞膜表达和蛋白稳定性的影响，并研究TIM-3棕榈酰化介导CTL/NK细胞耗竭的作用机制，提升了TIM-3棕榈酰化对TIM-3稳定表达的意义。并设计靶向TIM-3棕榈酰化位点的阻断多肽，提供靶向干预策略抑制TIM-3表达，为靶向干预TIM-3棕榈酰化的抗肿瘤免疫治疗提供了新的方向。