Fatty acid nanostructure lipid carrier for improving bioavailability of curcumin

The invention discloses a fatty acid nano-structure lipid carrier for improving bioavailability of curcumin, and belongs to the field of fine chemicals. Conjugated linoleic acid is used as liquid lipid, stearic acid is used as solid lipid, the curcumin-loaded nanostructure lipid carrier is prepared, and the biological acceptable rate of curcumin and the oxidation resistance of the system are improved. In a system embedded by a nano-structure lipid carrier (Cur-CLA-NLC) constructed by conjugated linoleic acid-stearic acid, the biological acceptable rate of curcumin is 85.7%, which is far higher than 11.7% of curcumin suspension (Cur-PBS) and 9.3% of curcumin, stearic acid and conjugated linoleic acid (Cur-SA-CLA) direct mixture system. Conjugated linoleic acid is used as liquid lipid in NLC, the lipid oxidation resistance of the system is enhanced, and CLA and curcumin have a synergistic anti-oxidation effect. 本发明公开了一种提高姜黄素生物可及度的脂肪酸纳米结构脂质载体，属于精细化学品领域。本发明以共轭亚油酸为液体脂质，硬脂酸为固体脂质，制备负载姜黄素的纳米结构脂质载体，提高了姜黄素的生物可接受率和体系的抗氧