IncRNA and application of antisense oligonucleotide thereof

The invention discloses lncRNA (long non-coding ribonucleic acid) and application of antisense oligonucleotide of the lncRNA. The lncRNA is lncRNA 857.1, and the nucleotide sequence of the lncRNA is shown as SEQ ID NO. 1. The nucleotide sequence of the antisense oligonucleotide is selected from SEQ...

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Hauptverfasser:	PU SHIQI, QU QINGSHENG, FANG YUJIA, QIAN PING, XU MEI, TANG XUDONG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses lncRNA (long non-coding ribonucleic acid) and application of antisense oligonucleotide of the lncRNA. The lncRNA is lncRNA 857.1, and the nucleotide sequence of the lncRNA is shown as SEQ ID NO. 1. The nucleotide sequence of the antisense oligonucleotide is selected from SEQ ID NO.2 to 3. The antisense oligonucleotide targeting lncRNA857.1 disclosed by the invention can effectively inhibit proliferation of nosema bombycis, and has a remarkable effect in preparation of RNAi medicines for preventing or treating diseases caused by nosema bombycis infection. 本发明公开了一种lncRNA及其反义寡核苷酸的应用，所述lncRNA为lncRNA857.1，其核苷酸序列如SEQ ID NO.1所示。所述反义寡核苷酸的核苷酸序列选自SEQ IDNO.2～3。本发明公开的靶向lncRNA857.1的反义寡核苷酸可有效抑制家蚕微孢子虫增殖，用于制备预防或治疗由家蚕微孢子虫感染引起的疾病的RNAi药物中效果显著。