SaRNA for promoting ABCG2 gene expression and application thereof

The invention belongs to the technical field of biological medicine, and relates to saRNA for promoting ABCG2 gene expression and application thereof. According to the present invention, the saRNA targeting the ABCG2 gene is designed for the first time, such that the human ABCG2saRNA is the saRNA-1 'and the saRNA-2', and the mouse ABCG2saRNA is the saRNA-1 'and the saRNA-2'; the saRNA is transfected into cells, and high expression of the ABCG2 gene is realized in human and mouse renal tubular epithelial cells respectively; through cell level and mouse model UA excretion experiments, it is proved that excretion of UA in cells and excretion of uric acid in blood into urine can be promoted by improving expression of the ABCG2 gene; an experimental basis is provided for preparing a small RNA (Ribonucleic Acid) medicine which takes ABCG2 as a target and is used for treating hyperuricemia or gout. 本发明属于生物医药技术领域，涉及一种促进ABCG2基因表达的saRNA及其应用；首次设计了靶向ABCG2基因的saRNA，包括人类ABCG2saRNA为saRNA-1′、saRNA-2′，小鼠ABCG2saRNA为：saRNA-1、saR