Salt of aza-fused ring amide compound, crystal form of salt and application of salt and crystal form of aza-fused ring amide compound

The invention relates to a salt of an aza-fused ring amide compound, a crystal form and an application thereof, and provides a salt of a compound shown as a formula (A-1), a salt of a compound shown as a formula (A-1) in a crystal form, a specific salt form and a crystal form thereof, a pharmaceutic...

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Hauptverfasser: WANG JIE, WANG YETING, GONG DENGHUANG, MI GUORUI, LIU XIBAO, MA ERQIAN, SUN JING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a salt of an aza-fused ring amide compound, a crystal form and an application thereof, and provides a salt of a compound shown as a formula (A-1), a salt of a compound shown as a formula (A-1) in a crystal form, a specific salt form and a crystal form thereof, a pharmaceutical composition containing the salt form and an application of the pharmaceutical composition, and preferably, the salt form has good crystallinity and stability. In-vivo and in-vitro pharmacological effects show that the salt of the compound shown as the formula (A-1) has a good inhibition effect on wild and mutant kinases, cells and in-vivo tumors, and has good patent medicine potential. 本发明涉及一种氮杂稠环酰胺类化合物的盐、其结晶形式及其用途,提供了一种如式(A-1)所示的化合物的盐、结晶形式的如式(A-1)所示的化合物的盐、具体盐型及其晶型、包含其的药物组合物及其用途,优选盐型具有良好的结晶度和稳定性,且体内外药效显示,式(A-1)所示的化合物的盐对野生型和突变型激酶、细胞及体内肿瘤均具有良好的抑制效果,具有良好的成药潜力。