Synthetic method of aza-tricyclic antibacterial compound
The invention belongs to the technical field of organic chemical synthesis, and relates to a synthetic method of an aza-tricyclic compound. The structural general formula is as shown in formula (I). Wherein R1, R2, R3, R4, R5, R6 and R7 are respectively and independently selected from hydrogen, a ha...
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| creator | JIA XIAOWEI WANG XIAOWEI CAO WEIKAI CAO HENGMING QI TAILIN HE HANJIANG |
| description | The invention belongs to the technical field of organic chemical synthesis, and relates to a synthetic method of an aza-tricyclic compound. The structural general formula is as shown in formula (I). Wherein R1, R2, R3, R4, R5, R6 and R7 are respectively and independently selected from hydrogen, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a cyano group, an ester group or NR8R9; wherein R8 and R9 are respectively and independently selected from hydrogen or C1-C6 alkyl; '---' is a bond or is absent; and 'A, B, C and D' are independently selected from a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom. The invention provides a synthetic method of aza-tricyclic derivatives, which comprises the following steps: by taking a compound conforming to the structure of a compound 1 as a raw material, carrying out acylation reaction, ring closing reaction, elimination reaction and reduction reaction on the compound and a compound conforming to the structure of a com |
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The structural general formula is as shown in formula (I). Wherein R1, R2, R3, R4, R5, R6 and R7 are respectively and independently selected from hydrogen, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a cyano group, an ester group or NR8R9; wherein R8 and R9 are respectively and independently selected from hydrogen or C1-C6 alkyl; '---' is a bond or is absent; and 'A, B, C and D' are independently selected from a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom. The invention provides a synthetic method of aza-tricyclic derivatives, which comprises the following steps: by taking a compound conforming to the structure of a compound 1 as a raw material, carrying out acylation reaction, ring closing reaction, elimination reaction and reduction reaction on the compound and a compound conforming to the structure of a com</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230516&DB=EPODOC&CC=CN&NR=116120316A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230516&DB=EPODOC&CC=CN&NR=116120316A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIA XIAOWEI</creatorcontrib><creatorcontrib>WANG XIAOWEI</creatorcontrib><creatorcontrib>CAO WEIKAI</creatorcontrib><creatorcontrib>CAO HENGMING</creatorcontrib><creatorcontrib>QI TAILIN</creatorcontrib><creatorcontrib>HE HANJIANG</creatorcontrib><title>Synthetic method of aza-tricyclic antibacterial compound</title><description>The invention belongs to the technical field of organic chemical synthesis, and relates to a synthetic method of an aza-tricyclic compound. The structural general formula is as shown in formula (I). Wherein R1, R2, R3, R4, R5, R6 and R7 are respectively and independently selected from hydrogen, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a cyano group, an ester group or NR8R9; wherein R8 and R9 are respectively and independently selected from hydrogen or C1-C6 alkyl; '---' is a bond or is absent; and 'A, B, C and D' are independently selected from a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom. The invention provides a synthetic method of aza-tricyclic derivatives, which comprises the following steps: by taking a compound conforming to the structure of a compound 1 as a raw material, carrying out acylation reaction, ring closing reaction, elimination reaction and reduction reaction on the compound and a compound conforming to the structure of a com</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAIrswryUgtyUxWyE0tychPUchPU0isStQtKcpMrkzOAYon5pVkJiUml6QWZSbmKCTn5xbkl-al8DCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxOTUvNSSeGc_Q0MzQyMDY0MzR2Ni1AAANRYuoQ</recordid><startdate>20230516</startdate><enddate>20230516</enddate><creator>JIA XIAOWEI</creator><creator>WANG XIAOWEI</creator><creator>CAO WEIKAI</creator><creator>CAO HENGMING</creator><creator>QI TAILIN</creator><creator>HE HANJIANG</creator><scope>EVB</scope></search><sort><creationdate>20230516</creationdate><title>Synthetic method of aza-tricyclic antibacterial compound</title><author>JIA XIAOWEI ; WANG XIAOWEI ; CAO WEIKAI ; CAO HENGMING ; QI TAILIN ; HE HANJIANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116120316A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JIA XIAOWEI</creatorcontrib><creatorcontrib>WANG XIAOWEI</creatorcontrib><creatorcontrib>CAO WEIKAI</creatorcontrib><creatorcontrib>CAO HENGMING</creatorcontrib><creatorcontrib>QI TAILIN</creatorcontrib><creatorcontrib>HE HANJIANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIA XIAOWEI</au><au>WANG XIAOWEI</au><au>CAO WEIKAI</au><au>CAO HENGMING</au><au>QI TAILIN</au><au>HE HANJIANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Synthetic method of aza-tricyclic antibacterial compound</title><date>2023-05-16</date><risdate>2023</risdate><abstract>The invention belongs to the technical field of organic chemical synthesis, and relates to a synthetic method of an aza-tricyclic compound. The structural general formula is as shown in formula (I). Wherein R1, R2, R3, R4, R5, R6 and R7 are respectively and independently selected from hydrogen, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a cyano group, an ester group or NR8R9; wherein R8 and R9 are respectively and independently selected from hydrogen or C1-C6 alkyl; '---' is a bond or is absent; and 'A, B, C and D' are independently selected from a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom. The invention provides a synthetic method of aza-tricyclic derivatives, which comprises the following steps: by taking a compound conforming to the structure of a compound 1 as a raw material, carrying out acylation reaction, ring closing reaction, elimination reaction and reduction reaction on the compound and a compound conforming to the structure of a com</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Synthetic method of aza-tricyclic antibacterial compound |
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