Synthetic method of aza-tricyclic antibacterial compound

The invention belongs to the technical field of organic chemical synthesis, and relates to a synthetic method of an aza-tricyclic compound. The structural general formula is as shown in formula (I). Wherein R1, R2, R3, R4, R5, R6 and R7 are respectively and independently selected from hydrogen, a ha...

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Hauptverfasser: JIA XIAOWEI, WANG XIAOWEI, CAO WEIKAI, CAO HENGMING, QI TAILIN, HE HANJIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of organic chemical synthesis, and relates to a synthetic method of an aza-tricyclic compound. The structural general formula is as shown in formula (I). Wherein R1, R2, R3, R4, R5, R6 and R7 are respectively and independently selected from hydrogen, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a cyano group, an ester group or NR8R9; wherein R8 and R9 are respectively and independently selected from hydrogen or C1-C6 alkyl; '---' is a bond or is absent; and 'A, B, C and D' are independently selected from a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom. The invention provides a synthetic method of aza-tricyclic derivatives, which comprises the following steps: by taking a compound conforming to the structure of a compound 1 as a raw material, carrying out acylation reaction, ring closing reaction, elimination reaction and reduction reaction on the compound and a compound conforming to the structure of a com