Pyrimidine compound containing hydroxamic acid fragment as well as preparation method and application of pyrimidine compound

The invention discloses a pyrimidine compound containing a hydroxamic acid fragment as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method of the pyrimidine compound containing the hydroxamic acid fragment comprises the following steps: (1) mixing a substituted 2, 4-dichloropyrimidine compound with an aminothiophene methyl ester compound, and carrying out nucleophilic substitution reaction to obtain a compound A; (2) mixing the compound A with different substituted aniline compounds in an acidic environment, and carrying out nucleophilic substitution reaction to obtain a compound B; and (3) mixing the compound B with hydroxylamine hydrochloride in an alkaline environment, and carrying out nucleophilic substitution reaction to obtain the pyrimidine compound containing the hydroxamic acid fragment. The pyrimidine compound containing the hydroxamic acid fragment is novel in structure, has good water solubility and has good application pros