Application of periplaneta americana extract in development of anti-hepatic fibrosis drugs

The invention discloses application of a periplaneta americana extract in development of anti-hepatic fibrosis drugs. The periplaneta americana extract SSAA has an anti-hepatic fibrosis effect in a CCl4 rat hepatic fibrosis model. In order to further research the anti-hepatic fibrosis molecular mechanism of the SSAA, the SSAA is planned to be used for intervening a CCl4 rat hepatic fibrosis model and an HSC-T6 cell strain cultured in vitro, proliferation and apoptosis of cells cultured in vitro are detected by a WST-8 method and a flow cytometry, expression of TGF-beta1/Smads, NF-kB and ERK/MAPK pathway protein and mRNA thereof in a model group and an in-vitro culture group is detected by Western blotting, ELISA and RT-PCR (reverse transcription-polymerase chain reaction), and the anti-hepatic fibrosis molecular mechanism of the SSAA is further researched. The invention aims to explain that SSAA inhibits activation and proliferation of HSC by interfering with the signal transduction pathway, promotes apoptosi