MRNA (messenger Ribonucleic Acid) for coding chicken infectious bursal disease virus antigen and mRNA vaccine thereof

The invention provides mRNA (messenger Ribonucleic Acid) for coding an infectious bursal disease virus antigen and an mRNA vaccine thereof. The mRNA at least contains at least one protein for coding the infectious bursal disease virus and/or a coding region of a fragment of at least one protein. The mRNA for coding the infectious bursal disease virus antigen is higher in production speed, more flexible and lower in cost, and cannot be integrated into a host genome, so that the basic safety is ensured. Meanwhile, the invention also discloses application of the mRNA for coding the infectious bursal disease virus antigen to preparation of the mRNA vaccine for preventing the infectious bursal disease and the mRNA vaccine, and compared with production of other complex vaccines, the vaccine disclosed by the invention is fast in reaction time and low in pollution risk. 本发明提供了一种编码鸡传染性法氏囊病病毒抗原的mRNA及其mRNA疫苗，所述mRNA至少含有编码鸡传染性法氏囊病病毒的至少一个蛋白，和/或至少一个蛋白的片段的编码区。本发明的编码鸡传染性法氏囊病病毒抗原的mRNA生产速度更快、更灵活、成本更低，不会被整合到宿主基因组中，保证了基本的安全性。同时，本