Pre-regulated mesenchymal stem cells as well as preparation and application thereof

The invention provides a pre-regulated mesenchymal stem cell, an exosome derived from the pre-regulated mesenchymal stem cell, and a cell protection composition containing the pre-regulated mesenchymal stem cell or the exosome. The present invention also provides a method of preparing a preconditioned mesenchymal stem cell by contacting a mesenchymal stem cell with an effective amount of ginkgolide A. The present invention also provides a method of promoting recovery of or reducing death of damaged nerve cells, comprising administering to the damaged nerve cells a composition comprising preregulated mesenchymal stem cells or exosomes. 本发明提供一种预调节间质干细胞、一种由其衍生的外泌体、以及一种包含预调节间质干细胞或外泌体的细胞保护组合物。本发明还提供一种透过将一间质干细胞与有效量的银杏内酯A接触以制备预调节间质干细胞的方法。本发明还提供一种促进受损神经细胞的恢复或减少其死亡的方法，包含向受损神经细胞施用包含预调节间质干细胞或外泌体的一组合物。