Probiotic composition and application thereof in intestinal diseases

The invention relates to a probiotic composition and application thereof in intestinal diseases. According to the interaction relationship between the alpha4beta7 integrin and MAdCAM-1, the active polypeptide capable of inhibiting the alpha4beta7 integrin with high specificity is screened from a polypeptide library, and the polypeptide is also identified to have a relatively good IC50 value. After the polypeptide and bifidobacterium are prepared into microcapsules together, enteritis reaction symptoms of mice can be remarkably reduced, and meanwhile expression of IL-10 is improved. 本发明涉及一种益生菌组合物及其在肠道疾病中的应用。本发明根据α4β7整合素和MAdCAM-1的互作关系，从多肽库筛选获得了能够高特异性的抑制α4β7整合素的活性多肽，该多肽也被鉴定具有较好的IC50值。将该多肽与双歧杆菌一起制备成为微胶囊之后，能够显著的降低小鼠的肠炎反应症状同时提高IL-10的表达。