Application of hyperphysiological dose androgen in improvement of prostatic cancer

The invention discloses an application of a super-physiological dose androgen in improvement of prostatic cancer, and the application concentration of the super-physiological dose androgen is in a range of 0.125 ng.mL to 32 ng.mL , so that the super-physiological dose androgen in the application concentration range is used for improving the prostatic cancer. Furthermore, the hyperphysiological dose androgen induces cell cycle arrest and induces cell apoptosis by inhibiting a PI3K/AKT/AR signal channel so as to inhibit proliferation of enzalutamide drug-resistant cell strain MDVR and hormone-insensitive prostate cancer cell line C4-2B cells, thereby improving the prostate cancer. 本申请示出了一种超生理剂量雄激素在改善前列腺癌中的应用，超生理剂量雄激素的应用浓度在0.125ng·mL-1至32ng·mL-1的范围内，以使该应用浓度范围内的超生理剂量雄激素用于改善前列腺癌。进一步的，超生理剂量雄激素通过抑制PI3K/AKT/AR信号通路以诱导细胞周期阻滞和诱导细胞凋亡以抑制恩杂鲁胺耐药细胞株MDVR和对激素不敏感前列腺癌细胞系C4-2B细胞的增殖，进而改善前列腺癌。