STABLE PHARMACEUTICAL FORMULATION

A stable pharmaceutical formulation according to the present invention comprises a recombinant fusion protein, a surfactant, a sugar or a derivative thereof, and a buffer. The stable pharmaceutical preparation according to the present invention has a low viscosity while containing a recombinant fusi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JIN GUANGYOU, OH JUN-SEOK, KIM SUJEONG, SHIN YEON KYEONG, HAN WON-YONG, LEE JAE-BEEN, NOH JI-WON
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:A stable pharmaceutical formulation according to the present invention comprises a recombinant fusion protein, a surfactant, a sugar or a derivative thereof, and a buffer. The stable pharmaceutical preparation according to the present invention has a low viscosity while containing a recombinant fusion protein, maintains excellent stability under long-term storage conditions, accelerated conditions, and severe conditions, and can be used for intraocular administration. 根据本发明的稳定的药物制剂包含重组融合蛋白、表面活性剂、糖或其衍生物以及缓冲剂。根据本发明的稳定的药物制剂在含有重组融合蛋白的同时具有低粘度,且在长期保存条件、加速条件和苛刻条件下保持优异的稳定性,可用于眼内给药。