Novel coronavirus fusion protein vaccine and application thereof

The invention provides a novel coronavirus fusion protein vaccine and application thereof. The vaccine comprises a recombinant fusion protein, a buffer solution, a stabilizer, a surfactant, sodium chloride and an adjuvant, and the recombinant fusion protein comprises interferon or a functional fragment thereof, novel coronavirus SARS-CoV-2 or a functional fragment thereof and IgG1Fc. The concentration of sodium chloride in the vaccine is maintained in a proper range, so that the stability of the vaccine is not negatively influenced, and the good adsorption rate of the aluminum adjuvant can be ensured. The vaccine disclosed by the invention has good high-temperature, oscillation and freeze-thaw stability. 本公开提供一种新型冠状病毒融合蛋白疫苗其应用。该疫苗包含重组融合蛋白、缓冲液、稳定剂、表面活性剂、氯化钠以及佐剂，其中，该重组融合蛋白包含干扰素或其功能片段、新型冠状病毒SARS-CoV-2或其功能片段以及IgG1Fc。将疫苗中的氯化钠浓度维持在合适的范围，既对疫苗的稳定性不造成负面影响，又能够保证铝佐剂的吸附率的良好吸附率。本公开的疫苗具有良好的高温、振荡、冻融稳定性。