Benzodiazepine derivatives useful for treatment of respiratory syncytial virus infections

Benzodiazepine derivatives useful for treatment of respiratory syncytial virus infections

A benzodiazepine derivative of formula (Ie) wherein one of R1 and R2 is a benzodiazepine-containing group of formula (II) wherein R8 is H or halogen; the other of R1 and R2 is a group Z selected from H, C3-C6 cycloalkyl, halogen,-NHR9, benzyl, phenyl, 4-to 10-membered heterocyclyl or 4-to 10-membere...

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Hauptverfasser: WARNER ANDREW JOHN, BARRETT MICHAEL, COCKERILL GARY SCOTT, GOOD JAMES, AVERY CHARLES A, COCHRANE EDWARD J, ONIONS STUART THOMAS, JONES STEVEN P
Format: Patent
Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A benzodiazepine derivative of formula (Ie) wherein one of R1 and R2 is a benzodiazepine-containing group of formula (II) wherein R8 is H or halogen; the other of R1 and R2 is a group Z selected from H, C3-C6 cycloalkyl, halogen,-NHR9, benzyl, phenyl, 4-to 10-membered heterocyclyl or 4-to 10-membered heteroaryl, where phenyl, heterocyclyl and heteroaryl are unsubstituted or substituted by one or two substituents selected from 4-to 10-membered heterocyclyl, which are unsubstituted or substituted by OR, where R1 is a hydrogen atom or a hydrogen atom, and R2 is a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom or a hydrogen atom. And selected from the group consisting of C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, halogen,-OR,-(CH2) mOR,-NR2,-(CH2) mNR2,-NHR ''