Mercaptopurine medication monitoring system for children with acute lymphatic leukemia
The invention relates to a mercaptopurine medication monitoring system for children with acute lymphatic leukemia. The treatment of 6-mercaptopurine is an important therapeutic drug for ALL children, but obvious hematotoxicity and hepatotoxicity can occur in the treatment process of 6-mercaptopurine...
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| creator | ZHOU YUE HAO GUOXIANG ZHENG YI ZHAO WEI YANG FAN WU KELIANG |
| description | The invention relates to a mercaptopurine medication monitoring system for children with acute lymphatic leukemia. The treatment of 6-mercaptopurine is an important therapeutic drug for ALL children, but obvious hematotoxicity and hepatotoxicity can occur in the treatment process of 6-mercaptopurine. In order to ensure the clinical curative effect of 6-MP and reduce the incidence rate of leukopenia and hepatotoxicity, the invention provides a mercaptopurine individualized treatment guidance method for children with acute lymphatic leukemia based on gene polymorphism and blood concentration monitoring and application. Based on the 6-MP metabolism related markers and the 6-TGN content in blood, a medication guidance system for Chinese acute lymphatic leukemia patients is established, and compared with a traditional scheme, the method disclosed by the invention is beneficial to realizing precise treatment.
本发明涉及一种急性淋巴白血病患儿巯嘌呤用药监测系统。6-巯基嘌呤治疗是ALL患儿的重要治疗药物，但该部分治疗过程会发生明显的血液毒性和肝毒性。为了确保6-MP的临床疗效，降低白细胞减少及肝毒性发生率，本发明提供了一 |
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本发明涉及一种急性淋巴白血病患儿巯嘌呤用药监测系统。6-巯基嘌呤治疗是ALL患儿的重要治疗药物，但该部分治疗过程会发生明显的血液毒性和肝毒性。为了确保6-MP的临床疗效，降低白细胞减少及肝毒性发生率，本发明提供了一</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230505&DB=EPODOC&CC=CN&NR=116064787A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230505&DB=EPODOC&CC=CN&NR=116064787A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHOU YUE</creatorcontrib><creatorcontrib>HAO GUOXIANG</creatorcontrib><creatorcontrib>ZHENG YI</creatorcontrib><creatorcontrib>ZHAO WEI</creatorcontrib><creatorcontrib>YANG FAN</creatorcontrib><creatorcontrib>WU KELIANG</creatorcontrib><title>Mercaptopurine medication monitoring system for children with acute lymphatic leukemia</title><description>The invention relates to a mercaptopurine medication monitoring system for children with acute lymphatic leukemia. The treatment of 6-mercaptopurine is an important therapeutic drug for ALL children, but obvious hematotoxicity and hepatotoxicity can occur in the treatment process of 6-mercaptopurine. In order to ensure the clinical curative effect of 6-MP and reduce the incidence rate of leukopenia and hepatotoxicity, the invention provides a mercaptopurine individualized treatment guidance method for children with acute lymphatic leukemia based on gene polymorphism and blood concentration monitoring and application. Based on the 6-MP metabolism related markers and the 6-TGN content in blood, a medication guidance system for Chinese acute lymphatic leukemia patients is established, and compared with a traditional scheme, the method disclosed by the invention is beneficial to realizing precise treatment.
本发明涉及一种急性淋巴白血病患儿巯嘌呤用药监测系统。6-巯基嘌呤治疗是ALL患儿的重要治疗药物，但该部分治疗过程会发生明显的血液毒性和肝毒性。为了确保6-MP的临床疗效，降低白细胞减少及肝毒性发生率，本发明提供了一</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNiz0KwkAUBtNYiHqH5wEEg5LYSlBstBLbsGy-JA_3j923SG5vCg9gNTDMLIvXHVGrID7kyA5k0bFWwt6R9Y7Fz3agNCWBpd5H0iObLsLRh2UkpbOAzGTDOE-aDPIbltW6WPTKJGx-XBXb6-XZ3HYIvkUKSsNB2uZRltW-Otan-nz4p_kCvQI6uQ</recordid><startdate>20230505</startdate><enddate>20230505</enddate><creator>ZHOU YUE</creator><creator>HAO GUOXIANG</creator><creator>ZHENG YI</creator><creator>ZHAO WEI</creator><creator>YANG FAN</creator><creator>WU KELIANG</creator><scope>EVB</scope></search><sort><creationdate>20230505</creationdate><title>Mercaptopurine medication monitoring system for children with acute lymphatic leukemia</title><author>ZHOU YUE ; HAO GUOXIANG ; ZHENG YI ; ZHAO WEI ; YANG FAN ; WU KELIANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116064787A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHOU YUE</creatorcontrib><creatorcontrib>HAO GUOXIANG</creatorcontrib><creatorcontrib>ZHENG YI</creatorcontrib><creatorcontrib>ZHAO WEI</creatorcontrib><creatorcontrib>YANG FAN</creatorcontrib><creatorcontrib>WU KELIANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHOU YUE</au><au>HAO GUOXIANG</au><au>ZHENG YI</au><au>ZHAO WEI</au><au>YANG FAN</au><au>WU KELIANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Mercaptopurine medication monitoring system for children with acute lymphatic leukemia</title><date>2023-05-05</date><risdate>2023</risdate><abstract>The invention relates to a mercaptopurine medication monitoring system for children with acute lymphatic leukemia. The treatment of 6-mercaptopurine is an important therapeutic drug for ALL children, but obvious hematotoxicity and hepatotoxicity can occur in the treatment process of 6-mercaptopurine. In order to ensure the clinical curative effect of 6-MP and reduce the incidence rate of leukopenia and hepatotoxicity, the invention provides a mercaptopurine individualized treatment guidance method for children with acute lymphatic leukemia based on gene polymorphism and blood concentration monitoring and application. Based on the 6-MP metabolism related markers and the 6-TGN content in blood, a medication guidance system for Chinese acute lymphatic leukemia patients is established, and compared with a traditional scheme, the method disclosed by the invention is beneficial to realizing precise treatment.
本发明涉及一种急性淋巴白血病患儿巯嘌呤用药监测系统。6-巯基嘌呤治疗是ALL患儿的重要治疗药物，但该部分治疗过程会发生明显的血液毒性和肝毒性。为了确保6-MP的临床疗效，降低白细胞减少及肝毒性发生率，本发明提供了一</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | Mercaptopurine medication monitoring system for children with acute lymphatic leukemia |
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