Mercaptopurine medication monitoring system for children with acute lymphatic leukemia

The invention relates to a mercaptopurine medication monitoring system for children with acute lymphatic leukemia. The treatment of 6-mercaptopurine is an important therapeutic drug for ALL children, but obvious hematotoxicity and hepatotoxicity can occur in the treatment process of 6-mercaptopurine...

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Hauptverfasser: ZHOU YUE, HAO GUOXIANG, ZHENG YI, ZHAO WEI, YANG FAN, WU KELIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a mercaptopurine medication monitoring system for children with acute lymphatic leukemia. The treatment of 6-mercaptopurine is an important therapeutic drug for ALL children, but obvious hematotoxicity and hepatotoxicity can occur in the treatment process of 6-mercaptopurine. In order to ensure the clinical curative effect of 6-MP and reduce the incidence rate of leukopenia and hepatotoxicity, the invention provides a mercaptopurine individualized treatment guidance method for children with acute lymphatic leukemia based on gene polymorphism and blood concentration monitoring and application. Based on the 6-MP metabolism related markers and the 6-TGN content in blood, a medication guidance system for Chinese acute lymphatic leukemia patients is established, and compared with a traditional scheme, the method disclosed by the invention is beneficial to realizing precise treatment. 本发明涉及一种急性淋巴白血病患儿巯嘌呤用药监测系统。6-巯基嘌呤治疗是ALL患儿的重要治疗药物,但该部分治疗过程会发生明显的血液毒性和肝毒性。为了确保6-MP的临床疗效,降低白细胞减少及肝毒性发生率,本发明提供了一