Tetrahydromethylpyrimidine carboxylic acid fermentation method

The invention relates to the technical field of amino acid derivative production, and discloses a tetrahydromethylpyrimidine carboxylic acid fermentation method which comprises the following steps: preparing a slant formula, a seed culture medium and a fermentation culture medium, culturing the seed culture medium in a seed tank, and culturing the fermentation culture medium in a fermentation tank. When tetrahydromethylpyrimidine carboxylic acid fermentation is carried out, escherichia coli is inoculated to a plate culture medium to obtain activated bacteria, the plate culture medium is inoculated with the obtained activated bacteria, the activated bacteria are transferred to a seed tank for continuous culture, and a seed culture solution is obtained; according to the method, the fermentation process is simple and easy to operate, and the fermentation production process is continuous, so that the quantity of products produced by fermentation of the tetrahydromethylpyrimidine carboxylic acid is increased. 本发明涉