SiRNA for inhibiting ABCB6 gene expression and application thereof

The embodiment of the invention discloses siRNA for inhibiting ABCB6 gene expression and application of the siRNA, and belongs to the technical field of biology. The siRNA is siABCB6-3 #, and the sequence of the siRNA is as follows: a sense strand: 5 '-GCUACCUGGUGUUCAAUGU-3', and an antise...

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Bibliographische Detailangaben
Hauptverfasser:	LIU SHUANG, CHEN LIZHI, YIN ZHAO, ZHANG QING, OU RUIMING, REES, LYU YIWEN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The embodiment of the invention discloses siRNA for inhibiting ABCB6 gene expression and application of the siRNA, and belongs to the technical field of biology. The siRNA is siABCB6-3 #, and the sequence of the siRNA is as follows: a sense strand: 5 '-GCUACCUGGUGUUCAAUGU-3', and an antisense strand: 5 '-ACAUGAACACCAGGUAGC-3'. The siRNA provided by the invention can effectively inhibit the expression of ABCB6 gene, can significantly inhibit the proliferation and clone formation ability of multiple myeloma cells, can promote ferroptosis, and can be applied to the preparation of drugs for preventing or treating multiple myeloma. 本发明实施例公开了一种抑制ABCB6基因表达的siRNA及其应用，属于生物技术领域。所述siRNA为siABCB6-3#，其序列为：正义链：5'-GCUACCUGGUGUUCAAUGU-3'；反义链：5'-ACAUUGAACACCAGGUAGC-3'。本发明的siRNA能有效抑制ABCB6基因的表达，并能够显著抑制多发性骨髓瘤细胞增殖和克隆形成能力，促进铁死亡，可应用于制备预防或治疗抗多发性骨髓瘤药物。