Universal monoclonal antibody HOPE1 for resisting natural capsaicin, dihydrocapsaicin and synthetic capsaicin and application of universal monoclonal antibody HOPE1
The invention discloses a universal monoclonal antibody HOPE1 for resisting natural capsaicin, dihydrocapsaicin and synthetic capsaicin and application of the universal monoclonal antibody HOPE1. The sequence of a heavy chain variable region of the universal monoclonal antibody HOPE1 is as shown in...
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| creator | LEI HONGTAO SHEN YUDONG CHEN RUNXI WANG ZHIRUO LUO LIN WANG YUPU CHEN ZIJIAN XU ZHENLIN WEN WEIHUAN ZENG HAILI |
| description | The invention discloses a universal monoclonal antibody HOPE1 for resisting natural capsaicin, dihydrocapsaicin and synthetic capsaicin and application of the universal monoclonal antibody HOPE1. The sequence of a heavy chain variable region of the universal monoclonal antibody HOPE1 is as shown in SEQ ID NO.1, and the sequence of a light chain variable region of the universal monoclonal antibody HOPE1 is as shown in SEQ ID NO.2. The half inhibition concentrations of the monoclonal antibody HOPE1 to natural capsaicin, synthetic capsaicin, dihydrocapsaicin and a mixture of the natural capsaicin, the synthetic capsaicin and the dihydrocapsaicin respectively reach 0.32 ng/mL, 0.07 ng/mL, 0.21 ng/mL and 103.8 pg/mL, and the monoclonal antibody HOPE1 has strong affinity to capsaicin substances; an ic-ELISA (Enzyme-Linked Immunosorbent Assay) immunodetection method and a time-resolved fluorescence immunochromatography method, which are established by the monoclonal antibody HOPE1 provided by the invention and are u |
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The sequence of a heavy chain variable region of the universal monoclonal antibody HOPE1 is as shown in SEQ ID NO.1, and the sequence of a light chain variable region of the universal monoclonal antibody HOPE1 is as shown in SEQ ID NO.2. The half inhibition concentrations of the monoclonal antibody HOPE1 to natural capsaicin, synthetic capsaicin, dihydrocapsaicin and a mixture of the natural capsaicin, the synthetic capsaicin and the dihydrocapsaicin respectively reach 0.32 ng/mL, 0.07 ng/mL, 0.21 ng/mL and 103.8 pg/mL, and the monoclonal antibody HOPE1 has strong affinity to capsaicin substances; an ic-ELISA (Enzyme-Linked Immunosorbent Assay) immunodetection method and a time-resolved fluorescence immunochromatography method, which are established by the monoclonal antibody HOPE1 provided by the invention and are u</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230505&DB=EPODOC&CC=CN&NR=116063538A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230505&DB=EPODOC&CC=CN&NR=116063538A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEI HONGTAO</creatorcontrib><creatorcontrib>SHEN YUDONG</creatorcontrib><creatorcontrib>CHEN RUNXI</creatorcontrib><creatorcontrib>WANG ZHIRUO</creatorcontrib><creatorcontrib>LUO LIN</creatorcontrib><creatorcontrib>WANG YUPU</creatorcontrib><creatorcontrib>CHEN ZIJIAN</creatorcontrib><creatorcontrib>XU ZHENLIN</creatorcontrib><creatorcontrib>WEN WEIHUAN</creatorcontrib><creatorcontrib>ZENG HAILI</creatorcontrib><title>Universal monoclonal antibody HOPE1 for resisting natural capsaicin, dihydrocapsaicin and synthetic capsaicin and application of universal monoclonal antibody HOPE1</title><description>The invention discloses a universal monoclonal antibody HOPE1 for resisting natural capsaicin, dihydrocapsaicin and synthetic capsaicin and application of the universal monoclonal antibody HOPE1. The sequence of a heavy chain variable region of the universal monoclonal antibody HOPE1 is as shown in SEQ ID NO.1, and the sequence of a light chain variable region of the universal monoclonal antibody HOPE1 is as shown in SEQ ID NO.2. 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The sequence of a heavy chain variable region of the universal monoclonal antibody HOPE1 is as shown in SEQ ID NO.1, and the sequence of a light chain variable region of the universal monoclonal antibody HOPE1 is as shown in SEQ ID NO.2. The half inhibition concentrations of the monoclonal antibody HOPE1 to natural capsaicin, synthetic capsaicin, dihydrocapsaicin and a mixture of the natural capsaicin, the synthetic capsaicin and the dihydrocapsaicin respectively reach 0.32 ng/mL, 0.07 ng/mL, 0.21 ng/mL and 103.8 pg/mL, and the monoclonal antibody HOPE1 has strong affinity to capsaicin substances; an ic-ELISA (Enzyme-Linked Immunosorbent Assay) immunodetection method and a time-resolved fluorescence immunochromatography method, which are established by the monoclonal antibody HOPE1 provided by the invention and are u</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | Universal monoclonal antibody HOPE1 for resisting natural capsaicin, dihydrocapsaicin and synthetic capsaicin and application of universal monoclonal antibody HOPE1 |
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