Sinomenine 1-substituted derivative as well as preparation method and application thereof

The invention belongs to the technical field of medicines and chemical engineering, and discloses sinomenine 1-substituted derivatives as well as a preparation method and application thereof. According to the invention, sinomenine is taken as a lead compound, and derivatives with different amide substituents or aromatic rings introduced at the site 1 of sinomenine are prepared through simple reaction and high yield, and part of the compounds have a remarkable anti-proliferation effect on cancer cells; the compound and the pharmaceutically acceptable salt thereof have great potential in preparation of antitumor drugs. 本发明属于药物及化工的技术领域，公开了一类青藤碱1位取代衍生物及其制备方法和应用。本发明以青藤碱为先导化合物通过简单反应和较高收率制备得到的一类青藤碱1位引入不同酰胺取代基或芳环的衍生物，并且部分化合物对癌细胞表现出显著的抗增殖作用，所述化合物及其药学上可接受的盐在制备抗肿瘤药物具有较大潜力。