Porous devices and methods of use

The present invention provides a porous device for processing a fluid sample, comprising a plate having a plurality of pores, each pore comprising a first sub-pore and a second sub-pore separated by a separate dialysis membrane; each individual dialysis membrane has a top end and a bottom end, with a continuous taper from the top end to the bottom end, each first sub-aperture and each second sub-aperture having an upper end and a lower end and sidewalls, one of which is a common sidewall shared by the first sub-aperture and the second sub-aperture, the common sidewall having a continuous tapered cutout, the individual dialysis membranes are fluid-tight sealed in the continuous tapered cutouts. 本发明提供了一种用于处理流体样品的多孔装置，包括具有多个孔的板，每个孔包括由单独的透析膜分隔开的第一子孔和第二子孔；每个单独的透析膜具有顶端部和底端部，具有从顶端部到底端部的连续锥形，每个第一子孔和每个第二子孔具有上端部和下端部以及侧壁，其中一个侧壁是由第一子孔和第二子孔共用的公共侧壁，该公共侧壁具有连续锥形切口，所述单独的透析膜不透流体地密封在连续锥形切口中。