New midazolam hydrochloride crystal form and preparation method thereof

The invention relates to the field of medicine crystal forms, in particular to midazolam hydrochloride crystal forms III and VI and a preparation method thereof. The obtained crystal form III of the compound shown in the formula (I) has good physical stability and chemical stability, the used crystallization solvent is low in toxicity and residue, and the crystal form III is more suitable for large-scale production and amplification. 本申请涉及药物晶型领域，具体涉及盐酸咪达唑仑晶型Ⅲ、Ⅵ及其制备方法。本发明所得到的式(I)化合物的晶型Ⅲ具有较好的物理稳定性和化学稳定性，并且所用结晶溶剂低毒低残留，更适合于大规模生产放大。