Quinazoline PAR4 antagonist and medical application thereof

The invention discloses a quinazoline PAR4 antagonist and medical application thereof, and particularly relates to a compound as shown in a formula (I), and pharmaceutically acceptable salt, ester or solvate thereof. Wherein R3 is a five-membered monoheterocyclic ring, a six-membered aryl group or a bicyclic heteroaryl group substituted by 0 to 3. The compounds can inhibit and prevent platelet aggregation induced by PAR4, and can be used for treating and preventing thromboembolic diseases, so that the compounds can be used as anti-platelet drugs. 本发明公开了一种喹唑啉类PAR4拮抗剂及其医药应用，具体如式(I)所示的化合物、其药学上可接受的盐、酯或溶剂化物。其中R3是被0至3个取代的五元单杂环、六元芳基或者二环杂芳基。这些化合物具有抑制和预防由PAR4诱导的血小板聚集，可用于治疗和预防血栓栓塞性疾病，因此可作为抗血小板药物。