Application of nitrogen-15 labeled compound in preparation of nitrogen-15 medicine for proton radiotherapy

The invention discloses application of a nitrogen-15 labeled compound in preparation of a nitrogen-15 medicine for proton radiotherapy, and belongs to the field of nuclear technology medical application. The nitrogen-15 labeled compound is free of toxic and side effects, tumor cells have specificity...

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Hauptverfasser: ZHU XING, LI YUXIAO, JIANG JUNKANG, ZHANG SHUYU, CHEN HONG, HU ZHIMIN, HE ZHENCEN, XU HAOYUE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application of a nitrogen-15 labeled compound in preparation of a nitrogen-15 medicine for proton radiotherapy, and belongs to the field of nuclear technology medical application. The nitrogen-15 labeled compound is free of toxic and side effects, tumor cells have specificity on uptake of the nitrogen-15 labeled compound, and the nitrogen-15 concentration ratio different from that in normal cells of a tumor part can be generated in the tumor cells, so that a larger cross section where proton induces nitrogen-15 to generate a cellular level nuclear reaction can be obtained, and the killing efficiency on the tumor cells is higher; the treatment cycle can be shortened, so that the duration of irradiating normal cells by protons is shortened, and the radiation damage to the normal cells is further reduced. The adopted proton beam technology is mature and wide in clinical application, and compared with a thermal neutron source in a BNCT scheme, the equipment construction cost is lower, and