Application of RNA helicase DHX33 inhibitor in preparation of medicine for treating prostatic cancer

The invention belongs to the field of biological medicine, and discloses application of an RNA helicase DHX33 inhibitor in preparation of drugs for treatment or adjuvant treatment of prostatic cancer. The important effect of DHX33 protein in prostatic cancer development is determined, the provided RNA helicase DHX33 inhibitor has the effect of inhibiting DHX33 helicase activity, lipid peroxidation mediated by DHX33 function deficiency is further caused, the inhibitor can rapidly induce cancer cell ferroptosis caused by lipid metabolism abnormality, and the prostatic cancer cell can be used for preparing prostatic cancer cells. The compound has obvious inhibition on prostate cancer cells, so that the compound has important medical development value. 本发明属于生物医药领域，公开了RNA解旋酶DHX33抑制剂在制备用于治疗或者辅助治疗前列腺癌的药物中的应用。本发明确立了DHX33蛋白在前列腺癌发展中的重要作用，提供的RNA解旋酶DHX33抑制剂具有抑制DHX33解旋酶活力的作用，进而导致由DHX33功能缺失所介导的脂质过氧化，该抑制剂可以快速诱导经由脂类代谢异常所导致的癌细胞铁死亡，对前列腺癌细胞具有显著的抑制性，因此具有重要的医药开发价值。