DNA information storage method based on natural and non-natural basic groups

The invention relates to a DNA information storage method based on natural and non-natural bases. The DNA information storage method comprises the following steps: extracting data information to be stored; designing a coding table, wherein the coding table is formed by mapping DNA information and data information units; sequentially confirming DNA information corresponding to the split data information in a coding table according to the split data information; sequentially arranging the DNA information in hole sites of a physical medium according to a sequence to obtain a DNA information storage carrier; during reading, DNA information is read in a mass spectrum mode and decoded. According to the storage and reading method disclosed by the invention, natural and non-natural basic groups can be fully utilized, multi-system coding is realized, and the density is expected to exceed 8bits/nt; meanwhile, the trouble that DNA needs to be synthesized from the beginning for information storage is avoided; in addition