Efficient and safe antibacterial peptide variant and application thereof
The invention discloses an efficient and safe antibacterial peptide variant and application thereof, which is characterized in that a natural antibacterial peptide Upin3.6 sequence (as shown in SEQ NO: 1) is used as a basis, and a disordered N-terminal segment of the natural antibacterial peptide Up...
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| creator | ZHANG XUECHENG FANG WEI XIAO YAZHONG LYU MENGQI ZHANG YINLIANG SHENG HAICHAO |
| description | The invention discloses an efficient and safe antibacterial peptide variant and application thereof, which is characterized in that a natural antibacterial peptide Upin3.6 sequence (as shown in SEQ NO: 1) is used as a basis, and a disordered N-terminal segment of the natural antibacterial peptide Upin3.6 sequence is replaced by basic amino acid arginine; repeating the two amyloid C-terminal sequences and adding three arginines to each of the two ends of the amyloid C-terminal sequences; and inserting a tetra-amino acid sequence DPDG (DPDG has the greatest tendency to form a beta-turn structure) between the two repeated amyloid C-terminal sequences, and adding three arginines to each of the two ends of the tetra-amino acid sequence DPDG. According to the antibacterial peptide, the activity and safety of the antibacterial peptide can be improved, the antibacterial peptide has good antibacterial performance on gram-negative bacteria and gram-positive bacteria, and the antibacterial peptide serving as a novel ant |
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| subjects | CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
| title | Efficient and safe antibacterial peptide variant and application thereof |
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