Efficient and safe antibacterial peptide variant and application thereof

The invention discloses an efficient and safe antibacterial peptide variant and application thereof, which is characterized in that a natural antibacterial peptide Upin3.6 sequence (as shown in SEQ NO: 1) is used as a basis, and a disordered N-terminal segment of the natural antibacterial peptide Upin3.6 sequence is replaced by basic amino acid arginine; repeating the two amyloid C-terminal sequences and adding three arginines to each of the two ends of the amyloid C-terminal sequences; and inserting a tetra-amino acid sequence DPDG (DPDG has the greatest tendency to form a beta-turn structure) between the two repeated amyloid C-terminal sequences, and adding three arginines to each of the two ends of the tetra-amino acid sequence DPDG. According to the antibacterial peptide, the activity and safety of the antibacterial peptide can be improved, the antibacterial peptide has good antibacterial performance on gram-negative bacteria and gram-positive bacteria, and the antibacterial peptide serving as a novel ant