Tetrahydrofuran-containing polycyclic derivative, pharmaceutically acceptable salt thereof, and preparation method and application of tetrahydrofuran-containing polycyclic derivative

The invention relates to a tetrahydrofuran-containing polycyclic derivative, a pharmaceutically acceptable salt thereof, and a preparation method and an application of the tetrahydrofuran-containing polycyclic derivative. In particular, the present invention relates to a compound represented by general formula (I), a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, and a use thereof as a CDK2 inhibitor in the treatment of cancer. Wherein each substituent in the general formula (I) is as defined in the specification. 本发明涉及一种含四氢呋喃多环类衍生物、其药学上可接受的盐及其制备方法和应用。特别地，本发明涉及通式(I)所示的化合物、其药学上可接受的盐和含有该化合物的药物组合物，以及其作为CDK2抑制剂在治疗癌症中的用途。其中通式(I)中的各取代基与说明书中的定义相同。