Acellular dermal matrix as well as preparation method and application thereof

The invention provides an acellular dermal matrix. Wherein the collagen content of the acellular dermal matrix is 92 to 98 weight percent; the acellular dermal matrix is derived from animal fetal skin; the animal fetal skin is selected from at least one of fetal calfskin, fetal pigskin or fetal sheepskin; preferably, the animal fetal skin is selected from fetal calfskin. The acellular dermal matrix further comprises inorganic ions, and the content of the inorganic ions is 0.01-0.2 wt%; the inorganic ion is selected from at least one of Mg < 2 + >, Zn < 2 + >, Cu < 2 + > and Ag < + >, preferably Cu < 2 + >. The acellular dermal matrix prepared by the method provided by the invention has good biocompatibility and vascularization promotion effect, can reduce secretion of inflammatory cytokines, can effectively improve the healing rate of chronic difficult-to-heal wounds, and provides a solution for clinical treatment of chronic difficult-to-heal wounds. 本申请提供了一种脱细胞真皮基质；其中，脱细胞真皮基质的胶原蛋白含量为92-98wt％；脱细胞真皮基质来源于动物胎皮；动