Capsid protein mutant MutF for improving AAV retina targeting property and application of capsid protein mutant MutF

The invention discloses a capsid protein mutant MutF capable of improving AAV retina targeting and application of the capsid protein mutant MutF. According to the research of the inventor, the capsid protein mutant MutF obtained by replacing 561-588 amino acids of wild type AAV2 virus capsid protein...

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Bibliographische Detailangaben
Hauptverfasser:	LIU HUAQING, YUAN LI, GAO CUI, ZHENG QIN, LI XIDAN, ZHANG QIXING, WU CHENGUANG, REN SHENG, ZENG ZHANCHENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a capsid protein mutant MutF capable of improving AAV retina targeting and application of the capsid protein mutant MutF. According to the research of the inventor, the capsid protein mutant MutF obtained by replacing 561-588 amino acids of wild type AAV2 virus capsid protein with DENEIRTTNPVATEQYGDVSTNLQRGNR is surprisingly capable of effectively improving the retina infection ability of the AAV2 virus and fundamentally solving the problem of retina targeting of the AAV2 virus. 本发明公开了提高AAV视网膜靶向性的衣壳蛋白突变体MutF及其应用。发明人研究发现，使用DENEIRTTNPVATEQYGDVSTNLQRGNR替换野生型AAV2病毒衣壳蛋白的561-588位氨基酸得到的衣壳蛋白突变体MutF，出人意料地可以有效提高AAV病毒视网膜感染能力，从根本上解决AAV2视网膜靶向性的问题。