Bone tissue engineering scaffold with slow release effect as well as preparation method and application of bone tissue engineering scaffold

The invention discloses a bone tissue engineering scaffold with a slow release effect as well as a preparation method and application thereof, and belongs to the field of biological materials. The bone tissue engineering scaffold is formed by combining a dense layer formed by compounding hydroxyapat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LYU YUPENG, ZHANG HUANQING, HUANG SHENGYUN, WANG YINCHUAN, XIAO GUIYONG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a bone tissue engineering scaffold with a slow release effect as well as a preparation method and application thereof, and belongs to the field of biological materials. The bone tissue engineering scaffold is formed by combining a dense layer formed by compounding hydroxyapatite fibers and gelatin and a loose porous layer constructed by gelatin, the dense layer can effectively prevent fibroblasts from growing into the scaffold, the loose porous layer is appropriate in aperture, osteoblasts can conveniently climb into the scaffold, the components do not contain harmful substances, the biocompatibility is high, and the scaffold is suitable for being used in the field of bone tissue engineering. The structure is manufactured by imitating the structure of a normal human bone, so that the microstructure at the through bone defect can be better reproduced, and the microstructure can be conveniently recovered in the healing process. The design of the scaffold is very flexible, different metal