Japanese encephalitis attenuated live vaccine and protective agent thereof

The invention provides a protective agent for Japanese encephalitis live attenuated vaccines. The protective agent is prepared from the following components in parts by weight: 3 to 5 parts of cane sugar, 3 to 5 parts of lactose, 0.5 to 1 part of gelatin, 0.2 to 0.5 part of urea and 0.1 to 0.5 part...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG XUANYONG, ZHOU WEI, LIU SHAOXIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a protective agent for Japanese encephalitis live attenuated vaccines. The protective agent is prepared from the following components in parts by weight: 3 to 5 parts of cane sugar, 3 to 5 parts of lactose, 0.5 to 1 part of gelatin, 0.2 to 0.5 part of urea and 0.1 to 0.5 part of human serum albumin. The protective agent can effectively protect the virulence of the Japanese encephalitis attenuated virus, the titer loss is reduced in the freeze-drying process, the excellent freeze-drying effect is ensured, and the prepared Japanese encephalitis attenuated live vaccine freeze-drying preparation can be stored for a long time and is excellent in stability. 本发明提供了一种乙型脑炎减毒活疫苗保护剂,包括如下各重量份数的组分:蔗糖:3~5份,乳糖:3~5份,明胶:0.5~1份,尿素:0.2~0.5份,人血白蛋白:0.1~0.5份。本发明保护剂能够有效保护乙型脑炎减毒病毒的毒力,在冻干过程中减少滴度损耗,并且确保优异的冻干效果,制得的乙型脑炎减毒活疫苗冻干制剂能够长期存放,稳定性优异。