Means and methods for detecting anomalous erythroblasts

The present invention relates to a method for detecting, diagnosing, monitoring or predicting a pathological condition in the bone marrow of a subject, said method comprising at least the step of determining the presence of abnormal erythroblasts in a sample of a bodily fluid of the subject. Also envisaged is the use of aberrant erythroblasts as a marker for diagnosing, detecting, monitoring or predicting a pathological condition in the bone marrow of a subject, as well as a kit for diagnosing, detecting, monitoring or predicting a pathological condition in the bone marrow of a subject, comprising means for determining the presence in a sample of a subject of (i) CD71 and/or GPA, (ii) CD45, (iii) nucleic acids of rare circulating cells, and at least one of (iv) EpCam or (v) a waveform protein. 本发明涉及用于检测、诊断、监测或预测受试者骨髓中病理状态的方法，所述方法至少包括确定受试者体液样品中异常成红细胞的存在的步骤。还设想了异常成红细胞作为用于诊断、检测、监测或预测受试者骨髓中病理状态的标记的用途，以及用于诊断、检测、监测或预测受试者骨髓中病理状态的套件，其包括用于确定受试者样品中存在以下项的工具：(i)CD71和/或GPA，(ii)CD45，(iii)稀有循环细胞的核酸，以及(iv)EpCam或(v)波形蛋白中的至少一种