Completely humanized antibody targeting CD7 and application thereof

The invention provides a fully humanized antibody targeting CD7 and application of the fully humanized antibody. The CD7-targeted fully humanized antibody is specifically combined with CD7 with high affinity, and compared with a heterologous antibody, the CD7-targeted fully humanized antibody has lo...

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Bibliographische Detailangaben
Hauptverfasser:	LI TONG, TAN TAOCHAO, JIA XIANGYIN, WEI QIAOE, XIE MENG, ZHANG QIANQIAN, LIU JIANWEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The invention provides a fully humanized antibody targeting CD7 and application of the fully humanized antibody. The CD7-targeted fully humanized antibody is specifically combined with CD7 with high affinity, and compared with a heterologous antibody, the CD7-targeted fully humanized antibody has lower immunogenicity and has good application potential in development of antibody drugs including monoclonal antibodies, double antibodies, antibody coupling drugs and the like and cell therapy drugs including CAR-T, CAR-NK and the like. 本发明提供了一种靶向CD7的全人源抗体及其应用。所述靶向CD7的全人源抗体以高亲和力特异性结合CD7，且与异源抗体相比，具有更低的免疫原性，在包括单抗、双抗、抗体偶联药物等在内的抗体药物及包括CAR-T，CAR-NK等在内的细胞治疗药物的开发上有很好的应用潜力。