Mesothelin targeting antibody, chimeric antigen receptor and application thereof

The present invention discloses anti-mesothelin antibodies and antigen binding fragments, chimeric antigen receptors ("CAR") ("mesothelin CAR") having such anti-mesothelin antibodies and antigen binding fragments, and genetically engineered immune effector cells having such mesothelin CAR. The invention also provides polynucleotides encoding anti-mesothelin antibodies and antigen binding fragments, and mesothelin CAR. The invention also provides compositions comprising anti-mesothelin antibodies and antigen binding fragments and mesothelin CARs. The invention also relates to said anti-mesothelin antibodies and antigen binding fragments, as well as to the use of genetically engineered immune effector cells with such mesothelin CARs in the treatment of cancer. 本发明公开了抗间皮素抗体和抗原结合片段、具有此类抗间皮素抗体和抗原结合片段的嵌合抗原受体("CAR")("间皮素CAR")以及具有此类间皮素CAR的基因工程化改造的免疫效应细胞。本发明还提供了编码抗间皮素抗体及抗原结合片段，和间皮素CAR的多核苷酸。本发明还提供了包含抗间皮素抗体和抗原结合片段以及间皮素CAR的组合物。本发明还涉及所述抗间皮素抗体及抗原结合片段，以及具有此类间皮素CAR的基因工程化改造的免疫效应细胞在癌症治疗中的用途。