Method for separating and purifying (-) gamma-lactam

The invention belongs to the technical field of bioengineering, and discloses a method for separating and purifying (-) gamma-lactam. By regulating and controlling physical and chemical factors in a reaction system, (+) gamma-lactam in (+/-) gamma-lactam is degraded with high stereoselectivity by ut...

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Bibliographische Detailangaben
Hauptverfasser:	WANG CONG, LIU CHUNYING, CHI XUEMEI, XIA SHUIYING, CHI NAIYU, YU SHUANG, GUO XINZHI, YUAN WENTAO, ZHANG QINGFANG, WANG YAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention belongs to the technical field of bioengineering, and discloses a method for separating and purifying (-) gamma-lactam. By regulating and controlling physical and chemical factors in a reaction system, (+) gamma-lactam in (+/-) gamma-lactam is degraded with high stereoselectivity by utilizing the screened strain for producing (+) gamma-lactamase to obtain (-) gamma-lactam, and then the (-) gamma-lactam is separated and purified so as to meet the requirements of industrial production. 本发明属于生物工程技术领域，公开了一种分离提纯(-)γ-内酰胺的方法。通过调控反应体系中的理化因素，利用筛选得到的产(+)γ-内酰胺酶菌株高立体选择性降解(±)γ-内酰胺中的(+)γ-内酰胺，得到(-)γ-内酰胺，进而对(-)γ-内酰胺进行分离提纯，以期来满足工业生产的需要。