Preparation method of flavonoid piperil hydrochloride

The invention discloses a preparation method of flavonoid piperazine hydrochloride. The preparation method comprises the following steps: S1, preparing 3-methyl flavone-8-carboxylic acid; s2, preparation of 2-piperidinyl ethanol: carrying out a reaction on chlorohydrin and hexahydropyridine to obtai...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LI GUOSONG, YUE ZHENGYA, LI YONGMIN, LIU SHAOJIE, HAN SHUAI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a preparation method of flavonoid piperazine hydrochloride. The preparation method comprises the following steps: S1, preparing 3-methyl flavone-8-carboxylic acid; s2, preparation of 2-piperidinyl ethanol: carrying out a reaction on chlorohydrin and hexahydropyridine to obtain the 2-piperidinyl ethanol; s3, preparing the flavonoid piperidyl hydrochloride, namely chlorinating the 3-methyl flavone-8-formic acid prepared in the step S1 by thionyl chloride to obtain acyl chloride, and performing esterification reaction on the acyl chloride and the 2-piperidyl ethanol prepared in the step S2 to obtain the flavonoid piperidyl hydrochloride. According to the preparation method disclosed by the invention, the yield and storage capacity of the raw materials 3-methyl flavone-8-carboxylic acid and 2-piperidinyl ethanol can be obtained in time through the raw materials 3-methyl flavone-8-carboxylic acid and 2-piperidinyl ethanol for preparing the flavonoid piperazine hydrochloride, so that the yie