Aromatic ring substituted pyridine quaternary ammonium salt derivative as well as preparation method and application thereof

The invention belongs to the field of new drug compounds, and particularly relates to an aromatic ring substituted pyridine quaternary ammonium salt derivative as well as a preparation method and application thereof. The aromatic ring substituted pyridine quaternary ammonium salt derivative is completely different from a reported FtsZ inhibitor parent nucleus structure and has different physicochemical properties, and experiments show that the derivative has an effect of inhibiting FtsZ, can be used as a novel FtsZ inhibitor and also has good antibacterial activity. 本发明属于新药物化合物领域，具体涉及芳香环取代的吡啶季铵盐类衍生物及其制备方法和应用。本发明的芳香环取代的吡啶季铵盐类衍生物与已报道的FtsZ抑制剂母核结构完全不同，具有不同的理化性质，经实验表明，该类衍生物具有抑制FtsZ的作用，可以作为新型FtsZ抑制剂，还具有良好的抗菌活性。