Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of diseases associated with PI3K modulation
The present disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s and ring A are as described herein, or prodrugs, solvates, enantiomers, stereoisomers, tautomers or pharmaceutically acceptable salts thereof, as allochromenone inhibitors of phosphoino...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KLIPPEL-GISSE ANDREAS ARONOV SERGEY DMITRIEVICH WELCH MATTHEW B LONG KIMBERLY F VIJAJA TAPANI KOLAKOWSKI GABRIELLE R BOYLES NATHAN A KACICKI EDWARD A KNIGHT JAMES L FENG SHULU MCLIGGOTT DANIEL L MCCLAIN JOHN A SEVERANCE DAVID L IRWIN TIMOTHY C E. D. ANDERSON DAHLGREN MARIA KATHARINA HICKEY ELLEN R KUMAR MUKESH L. PUCA GERASCIUTO ANTHONY I MEYN CHRISTOPHER G RAVI KSHITIJ K |
| description | The present disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s and ring A are as described herein, or prodrugs, solvates, enantiomers, stereoisomers, tautomers or pharmaceutically acceptable salts thereof, as allochromenone inhibitors of phosphoinositide 3-kinase (PI3K), useful in the treatment of diseases or disorders associated with PI3K modulation.
本公开内容涉及可用于治疗与PI3K调节相关的疾病或障碍的作为磷酸肌醇3-激酶(PI3K)的变构色烯酮抑制剂的式(I)的化合物或其前药、溶剂化物、对映异构体、立体异构体、互变异构体或药学上可接受的盐，，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、W、X、Y、s和环A如本文中所述。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN115956075A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN115956075A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN115956075A3</originalsourceid><addsrcrecordid>eNqNizEKwkAQRdNYiHqHsdMiYAhRLENQFEEs7MOanbCDm52wM5Lrm4AHsPi84r83T4bSe25c5A4DBwQKjl6kHAW4hd6xjKPAQkoWIU_fFIwgbB7X_LaFliNoRKNjrlNhSXD8BYwIN2QULQykDiYfOrYfb5Q4LJNZa7zg6sdFsj6fntUlxZ5rlN40GFDr6p5lxbHY7w5Fmf_jfAEuu0VO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of diseases associated with PI3K modulation</title><source>esp@cenet</source><creator>KLIPPEL-GISSE ANDREAS ; ARONOV SERGEY DMITRIEVICH ; WELCH MATTHEW B ; LONG KIMBERLY F ; VIJAJA TAPANI ; KOLAKOWSKI GABRIELLE R ; BOYLES NATHAN A ; KACICKI EDWARD A ; KNIGHT JAMES L ; FENG SHULU ; MCLIGGOTT DANIEL L ; MCCLAIN JOHN A ; SEVERANCE DAVID L ; IRWIN TIMOTHY C ; E. D. ANDERSON ; DAHLGREN MARIA KATHARINA ; HICKEY ELLEN R ; KUMAR MUKESH ; L. PUCA ; GERASCIUTO ANTHONY I ; MEYN CHRISTOPHER G ; RAVI KSHITIJ K</creator><creatorcontrib>KLIPPEL-GISSE ANDREAS ; ARONOV SERGEY DMITRIEVICH ; WELCH MATTHEW B ; LONG KIMBERLY F ; VIJAJA TAPANI ; KOLAKOWSKI GABRIELLE R ; BOYLES NATHAN A ; KACICKI EDWARD A ; KNIGHT JAMES L ; FENG SHULU ; MCLIGGOTT DANIEL L ; MCCLAIN JOHN A ; SEVERANCE DAVID L ; IRWIN TIMOTHY C ; E. D. ANDERSON ; DAHLGREN MARIA KATHARINA ; HICKEY ELLEN R ; KUMAR MUKESH ; L. PUCA ; GERASCIUTO ANTHONY I ; MEYN CHRISTOPHER G ; RAVI KSHITIJ K</creatorcontrib><description>The present disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s and ring A are as described herein, or prodrugs, solvates, enantiomers, stereoisomers, tautomers or pharmaceutically acceptable salts thereof, as allochromenone inhibitors of phosphoinositide 3-kinase (PI3K), useful in the treatment of diseases or disorders associated with PI3K modulation.
本公开内容涉及可用于治疗与PI3K调节相关的疾病或障碍的作为磷酸肌醇3-激酶(PI3K)的变构色烯酮抑制剂的式(I)的化合物或其前药、溶剂化物、对映异构体、立体异构体、互变异构体或药学上可接受的盐，，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、W、X、Y、s和环A如本文中所述。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230411&DB=EPODOC&CC=CN&NR=115956075A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230411&DB=EPODOC&CC=CN&NR=115956075A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KLIPPEL-GISSE ANDREAS</creatorcontrib><creatorcontrib>ARONOV SERGEY DMITRIEVICH</creatorcontrib><creatorcontrib>WELCH MATTHEW B</creatorcontrib><creatorcontrib>LONG KIMBERLY F</creatorcontrib><creatorcontrib>VIJAJA TAPANI</creatorcontrib><creatorcontrib>KOLAKOWSKI GABRIELLE R</creatorcontrib><creatorcontrib>BOYLES NATHAN A</creatorcontrib><creatorcontrib>KACICKI EDWARD A</creatorcontrib><creatorcontrib>KNIGHT JAMES L</creatorcontrib><creatorcontrib>FENG SHULU</creatorcontrib><creatorcontrib>MCLIGGOTT DANIEL L</creatorcontrib><creatorcontrib>MCCLAIN JOHN A</creatorcontrib><creatorcontrib>SEVERANCE DAVID L</creatorcontrib><creatorcontrib>IRWIN TIMOTHY C</creatorcontrib><creatorcontrib>E. D. ANDERSON</creatorcontrib><creatorcontrib>DAHLGREN MARIA KATHARINA</creatorcontrib><creatorcontrib>HICKEY ELLEN R</creatorcontrib><creatorcontrib>KUMAR MUKESH</creatorcontrib><creatorcontrib>L. PUCA</creatorcontrib><creatorcontrib>GERASCIUTO ANTHONY I</creatorcontrib><creatorcontrib>MEYN CHRISTOPHER G</creatorcontrib><creatorcontrib>RAVI KSHITIJ K</creatorcontrib><title>Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of diseases associated with PI3K modulation</title><description>The present disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s and ring A are as described herein, or prodrugs, solvates, enantiomers, stereoisomers, tautomers or pharmaceutically acceptable salts thereof, as allochromenone inhibitors of phosphoinositide 3-kinase (PI3K), useful in the treatment of diseases or disorders associated with PI3K modulation.
本公开内容涉及可用于治疗与PI3K调节相关的疾病或障碍的作为磷酸肌醇3-激酶(PI3K)的变构色烯酮抑制剂的式(I)的化合物或其前药、溶剂化物、对映异构体、立体异构体、互变异构体或药学上可接受的盐，，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、W、X、Y、s和环A如本文中所述。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNizEKwkAQRdNYiHqHsdMiYAhRLENQFEEs7MOanbCDm52wM5Lrm4AHsPi84r83T4bSe25c5A4DBwQKjl6kHAW4hd6xjKPAQkoWIU_fFIwgbB7X_LaFliNoRKNjrlNhSXD8BYwIN2QULQykDiYfOrYfb5Q4LJNZa7zg6sdFsj6fntUlxZ5rlN40GFDr6p5lxbHY7w5Fmf_jfAEuu0VO</recordid><startdate>20230411</startdate><enddate>20230411</enddate><creator>KLIPPEL-GISSE ANDREAS</creator><creator>ARONOV SERGEY DMITRIEVICH</creator><creator>WELCH MATTHEW B</creator><creator>LONG KIMBERLY F</creator><creator>VIJAJA TAPANI</creator><creator>KOLAKOWSKI GABRIELLE R</creator><creator>BOYLES NATHAN A</creator><creator>KACICKI EDWARD A</creator><creator>KNIGHT JAMES L</creator><creator>FENG SHULU</creator><creator>MCLIGGOTT DANIEL L</creator><creator>MCCLAIN JOHN A</creator><creator>SEVERANCE DAVID L</creator><creator>IRWIN TIMOTHY C</creator><creator>E. D. ANDERSON</creator><creator>DAHLGREN MARIA KATHARINA</creator><creator>HICKEY ELLEN R</creator><creator>KUMAR MUKESH</creator><creator>L. PUCA</creator><creator>GERASCIUTO ANTHONY I</creator><creator>MEYN CHRISTOPHER G</creator><creator>RAVI KSHITIJ K</creator><scope>EVB</scope></search><sort><creationdate>20230411</creationdate><title>Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of diseases associated with PI3K modulation</title><author>KLIPPEL-GISSE ANDREAS ; ARONOV SERGEY DMITRIEVICH ; WELCH MATTHEW B ; LONG KIMBERLY F ; VIJAJA TAPANI ; KOLAKOWSKI GABRIELLE R ; BOYLES NATHAN A ; KACICKI EDWARD A ; KNIGHT JAMES L ; FENG SHULU ; MCLIGGOTT DANIEL L ; MCCLAIN JOHN A ; SEVERANCE DAVID L ; IRWIN TIMOTHY C ; E. D. ANDERSON ; DAHLGREN MARIA KATHARINA ; HICKEY ELLEN R ; KUMAR MUKESH ; L. PUCA ; GERASCIUTO ANTHONY I ; MEYN CHRISTOPHER G ; RAVI KSHITIJ K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115956075A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>KLIPPEL-GISSE ANDREAS</creatorcontrib><creatorcontrib>ARONOV SERGEY DMITRIEVICH</creatorcontrib><creatorcontrib>WELCH MATTHEW B</creatorcontrib><creatorcontrib>LONG KIMBERLY F</creatorcontrib><creatorcontrib>VIJAJA TAPANI</creatorcontrib><creatorcontrib>KOLAKOWSKI GABRIELLE R</creatorcontrib><creatorcontrib>BOYLES NATHAN A</creatorcontrib><creatorcontrib>KACICKI EDWARD A</creatorcontrib><creatorcontrib>KNIGHT JAMES L</creatorcontrib><creatorcontrib>FENG SHULU</creatorcontrib><creatorcontrib>MCLIGGOTT DANIEL L</creatorcontrib><creatorcontrib>MCCLAIN JOHN A</creatorcontrib><creatorcontrib>SEVERANCE DAVID L</creatorcontrib><creatorcontrib>IRWIN TIMOTHY C</creatorcontrib><creatorcontrib>E. D. ANDERSON</creatorcontrib><creatorcontrib>DAHLGREN MARIA KATHARINA</creatorcontrib><creatorcontrib>HICKEY ELLEN R</creatorcontrib><creatorcontrib>KUMAR MUKESH</creatorcontrib><creatorcontrib>L. PUCA</creatorcontrib><creatorcontrib>GERASCIUTO ANTHONY I</creatorcontrib><creatorcontrib>MEYN CHRISTOPHER G</creatorcontrib><creatorcontrib>RAVI KSHITIJ K</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KLIPPEL-GISSE ANDREAS</au><au>ARONOV SERGEY DMITRIEVICH</au><au>WELCH MATTHEW B</au><au>LONG KIMBERLY F</au><au>VIJAJA TAPANI</au><au>KOLAKOWSKI GABRIELLE R</au><au>BOYLES NATHAN A</au><au>KACICKI EDWARD A</au><au>KNIGHT JAMES L</au><au>FENG SHULU</au><au>MCLIGGOTT DANIEL L</au><au>MCCLAIN JOHN A</au><au>SEVERANCE DAVID L</au><au>IRWIN TIMOTHY C</au><au>E. D. ANDERSON</au><au>DAHLGREN MARIA KATHARINA</au><au>HICKEY ELLEN R</au><au>KUMAR MUKESH</au><au>L. PUCA</au><au>GERASCIUTO ANTHONY I</au><au>MEYN CHRISTOPHER G</au><au>RAVI KSHITIJ K</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of diseases associated with PI3K modulation</title><date>2023-04-11</date><risdate>2023</risdate><abstract>The present disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s and ring A are as described herein, or prodrugs, solvates, enantiomers, stereoisomers, tautomers or pharmaceutically acceptable salts thereof, as allochromenone inhibitors of phosphoinositide 3-kinase (PI3K), useful in the treatment of diseases or disorders associated with PI3K modulation.
本公开内容涉及可用于治疗与PI3K调节相关的疾病或障碍的作为磷酸肌醇3-激酶(PI3K)的变构色烯酮抑制剂的式(I)的化合物或其前药、溶剂化物、对映异构体、立体异构体、互变异构体或药学上可接受的盐，，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、W、X、Y、s和环A如本文中所述。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN115956075A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of diseases associated with PI3K modulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T19%3A18%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KLIPPEL-GISSE%20ANDREAS&rft.date=2023-04-11&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN115956075A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |