Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of diseases associated with PI3K modulation

Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of diseases associated with PI3K modulation

The present disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s and ring A are as described herein, or prodrugs, solvates, enantiomers, stereoisomers, tautomers or pharmaceutically acceptable salts thereof, as allochromenone inhibitors of phosphoino...

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Hauptverfasser: KLIPPEL-GISSE ANDREAS, ARONOV SERGEY DMITRIEVICH, WELCH MATTHEW B, LONG KIMBERLY F, VIJAJA TAPANI, KOLAKOWSKI GABRIELLE R, BOYLES NATHAN A, KACICKI EDWARD A, KNIGHT JAMES L, FENG SHULU, MCLIGGOTT DANIEL L, MCCLAIN JOHN A, SEVERANCE DAVID L, IRWIN TIMOTHY C, E. D. ANDERSON, DAHLGREN MARIA KATHARINA, HICKEY ELLEN R, KUMAR MUKESH, L. PUCA, GERASCIUTO ANTHONY I, MEYN CHRISTOPHER G, RAVI KSHITIJ K
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s and ring A are as described herein, or prodrugs, solvates, enantiomers, stereoisomers, tautomers or pharmaceutically acceptable salts thereof, as allochromenone inhibitors of phosphoinositide 3-kinase (PI3K), useful in the treatment of diseases or disorders associated with PI3K modulation. 本公开内容涉及可用于治疗与PI3K调节相关的疾病或障碍的作为磷酸肌醇3-激酶(PI3K)的变构色烯酮抑制剂的式(I)的化合物或其前药、溶剂化物、对映异构体、立体异构体、互变异构体或药学上可接受的盐，，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、W、X、Y、s和环A如本文中所述。